The main component is amino acids, nucleotide, vitamin, trace elements, inositol, folate, etc. Nutrient mixture is widely used in China.
In recent years, numerous functional food have been found to possess potent anti-aging activities, and as potential candidate for the development of anti-aging therapies 10. Hence, D-galactose-induced aging model has been admitted by researchers and been widely used in studying aging mechanism 9. It has been shown that D-gal induced animals express aging-associated changes in body physiology and phenotypes, such as cognitive dysfunction, increased oxidative stress, decreased antioxidant enzyme activity, diminished immune response and mitochondrial dysfunction 8.
96 HOUR CHICK EMBRYO SERIAL SECTION FREE
An excess of D-gal converts to aldose and hydrogen peroxide during the catalysis of galactose oxidase, and culminates in the generation of free radical, which eventually impairs cellular function 7.
In addition, antioxidant and immunostimulant have been reported to be beneficial to aging process 5.ĭ-gal as a sugar, which completely metabolizes at normal concentration, is a natural agent in the body 6. During the aging process, various pro-inflammatory molecules are generated to enhance inflammation cascade associated with different age-related pathologies 4. Yet, the imbalance of free radical metabolism damages cellular lipids, proteins and DNA, which cause the body aging 3. Over the past decades, it is well established that the aging process is associated with antioxidant defense system dysfunction, immune system impairment, cognitive and motor degeneration 2. Anti-aging has already become a major public issue with the increasing elderly population in the world.
96 HOUR CHICK EMBRYO SERIAL SECTION PLUS
Overall, these results seem to be implying that CE plus NM was used as potentially natural supplement or functional food for preventing aging.Īging, as a natural phenomenon, leads to progressive deterioration of tissues and organs 1. CE plus NM also inhibited the activation of TLR4/NF-κB pathway stimulated by LPS in splenic B lymphocytes. In addition, the biochemical index showed that CE plus NM could improve the antioxidant enzyme activity of the aging rats, decrease lipofuscin (LF) and glutamate content. CE plus NM also increased the spleen and thymus index as well as splenocyte proliferation, and reversed inflammatory cytokine levels. The results demonstrated that CE plus NM was superior treatment to improve the histopathologic changes and reverse learning and memory impairment of the aging rats. The organs and tissues were excised for histological study. At the end of experiment, serum and tissues were collected for immunity and antioxidation function. Cognitive function assessment was performed using the Morris water maze test. CE and NM were administered to aging rats through different dose gavage once a day. Aging was induced by administration of D-galactose (D-gal, 500 mg/kg/day for 90 days). The present paper was designed to investigate the anti-aging roles of chick embryo (CE) and nutrient mixture (NM) in aging rats. Aging is spontaneous and inevitable processes that lead to changes in biological systems.
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